A7819812
Tyrphostin 9 , ≥98% , 10537-47-0
Synonym(s):
[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AG 17 - CAS 10537-47-0 - Calbiochem;Malonoben;NSC 242557, 3,5-di- t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di- t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB159.20 | In Stock |
|
| 50MG | RMB289.60 | In Stock |
|
| 100MG | RMB591.20 | In Stock |
|
| 500MG | RMB1975.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 141-143℃ (ethanol ) |
| Boiling point: | 424.99°C (rough estimate) |
| Density | 1.0741 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | ethanol: 20 mg/mL |
| form | solid |
| pka | 7.55±0.40(Predicted) |
| color | yellow |
| biological source | synthetic (organic) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 10537-47-0(CAS DataBase Reference) |
| EPA Substance Registry System | Malonoben (10537-47-0) |
Description and Uses
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301+H311 |
| Precautionary statements | P264-P270-P280-P301+P310-P302+P352+P312-P361+P364 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OO3737000 |
| HS Code | 2926.90.5050 |
| HazardClass | 6.1 |
