3-(Trifluoromethyl)phenyl Isocyanate , >96.0%(GC) , 329-01-1

Synonym(s):
α,α,α-Trifluoro-m-tolyl isocyanate

CAS NO.：329-01-1

Empirical Formula: C8H4F3NO

Molecular Weight: 187.12

MDL number: MFCD00002020

EINECS: 206-341-3

PRODUCT Properties

• Melting point: -26 °C
• Boiling point: 54 °C11 mm Hg(lit.)
• Density: 1.359 g/mL at 25 °C(lit.)
• vapor pressure: 2.44 psi ( 20 °C)
• refractive index: n20/D 1.467(lit.)
• Flash point: 138 °F
• storage temp.: Keep Cold
• solubility: soluble in Toluene
• form: clear liquid
• color: Colorless to Almost colorless
• Specific Gravity: 1.359
• Water Solubility: 5.46g/L at 25℃
• Sensitive: Lachrymatory
• BRN: 744880
• LogP: 2.04
• CAS DataBase Reference: 329-01-1(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isocyanato-3-(trifluoromethyl)-(329-01-1)
• EPA Substance Registry System: 3-Trifluoromethylphenyl isocyanate (329-01-1)

Description and Uses

3-?(Trifluoromethyl)?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives.

Safety

• Symbol(GHS): GHS02,GHS05,GHS06,GHS09
• Signal word: Danger
• Hazard statements: H226-H302-H311-H315-H317-H318-H330-H335-H411
• Precautionary statements: P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: Xn,T,T+
• Risk Statements: 20/22-37/38-42-36/37/38-26-21/22-22
• Safety Statements: 23-28-45-36/37/39-28A-26-36/37-22-9
• RIDADR: UN 3384 6.1/PG 1
• WGK Germany: 2
• RTECS: NR0200000
• F: 10
• Hazard Note: Toxic/Lachrymatory/Keep Cold
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• HS Code: 29291090
• Limited Quantities: 100ml (liquid) or 0.5 Kg (solid)
• Excepted Quantities: Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)