1-<WBR>(2,3,4-<WBR>Trimethoxybenzyl)<WBR>piperazine dihydrochloride , 97% , 13171-25-0
Synonym(s):
Trimetazidine dihydrochloride
CAS NO.：13171-25-0
Empirical Formula: C14H24Cl2N2O3
Molecular Weight: 339.26
MDL number: MFCD00243086
EINECS: 236-117-0
| Pack Size | Price | Stock | Quantity |
| 5g | RMB73.60 | In Stock |
|
| 10G | RMB127.20 | In Stock |
|
| 25G | RMB236.00 | In Stock |
|
| 100g | RMB889.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 231-235 °C(lit.) |
| storage temp. | Refrigerator |
| solubility | Freely soluble in water, sparingly soluble in alcohol. |
| form | Solid |
| color | White to Off-White |
| Merck | 14,9705 |
| Stability: | Hygroscopic |
| InChI | InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H |
| InChIKey | XIRALXKCBGTYSC-UHFFFAOYSA-N |
| SMILES | C1(C=CC(OC)=C(OC)C=1OC)CN1CCNCC1.Cl.Cl |
| CAS DataBase Reference | 13171-25-0(CAS DataBase Reference) |
Description and Uses
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | TM2976100 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Toxicity | LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey) |
