Valinomycin , ≥98%(TLC),≥95%(HPLC) , 2001-95-8

Synonym(s):
Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid;Valinomycin;Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

CAS NO.：2001-95-8

Empirical Formula: C54H90N6O18

Molecular Weight: 1111.32

MDL number: MFCD00005114

EINECS: 217-896-6

PRODUCT Properties

• Melting point: 187-190 °C
• alpha: D20 +31.0° (c = 1.6 in benzene)
• Boiling point: 821.74°C (rough estimate)
• Density: 1.060
• refractive index: 1.6400 (estimate)
• Flash point: 87℃
• storage temp.: 2-8°C
• solubility: DMSO: ≥10 mg/mL
• pka: 11.32±0.70(Predicted)
• form: solid
• color: white
• biological source: Streptomyces sp.
• optical activity: [α]20/D +32±2°, c = 1.6% in benzene
• Water Solubility: Soluble in DMSO at 10mg/ml. Insoluble in water
• Merck: 13,9976
• BRN: 78657
• Sequence: Cyclic({d-Hiv}-{d-Val}-{Lac}-Val-{d-Hiv}-{d-Val}-{Lac}-Val-{d-Hiv}-{d-Val}-{Lac}-Val)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
• EPA Substance Registry System: Valinomycin (2001-95-8)

Description and Uses

Valinomycin (2001-95-8) is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 Valinomycin can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3

antibiotic; LD50 (rat, po) 4 mg/kg

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310
• Precautionary statements: P262-P280-P301+P310+P330-P302+P352+P310
• Hazard Codes: Xn,T,T+,Xi
• Risk Statements: 27/28-36/37/38-21/22
• Safety Statements: 36-45-36/37-28-37/39-26
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: YV9468000
• F: 10-18-21
• TSCA: Yes
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29419090
• Hazardous Substances Data: 2001-95-8(Hazardous Substances Data)