Valdecoxib , ≥99% , 181695-72-7
Synonym(s):
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
CAS NO.：181695-72-7
Empirical Formula: C16H14N2O3S
Molecular Weight: 314.36
MDL number: MFCD00950568
EINECS: 803-082-3
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB95.20 | In Stock |
|
| 50MG | RMB183.20 | In Stock |
|
| 1g | RMB326.40 | In Stock |
|
| 5g | RMB1197.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 162-164°C |
| Boiling point: | 481.2±55.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >25mg/mL |
| form | powder |
| pka | 9.83±0.10(Predicted) |
| color | white to off-white |
| Henry's Law Constant | 4.5×105 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) |
| InChIKey | LNPDTQAFDNKSHK-UHFFFAOYSA-N |
| SMILES | C1(S(N)(=O)=O)=CC=C(C2=C(C)ON=C2C2=CC=CC=C2)C=C1 |
| CAS DataBase Reference | 181695-72-7(CAS DataBase Reference) |
Description and Uses
Valdecoxib is a second-generation COX-2 inhibitor, developed as a follow-up to celecoxib for the oral once-daily treatment of osteoarthritis, adult rheumatoid arthritis and menstrual pain. Valdecoxib is approximately 28,000-fold more selective against human recombinant COX-2 than human recombinant COX-1. In an ex viva human whole blood assay, the I&O values against COX-2 and COX-1 were respectively 0.89 PM and 25.4 FM. In animal models, valdecoxib possesses excellent oral activity as an antiinflammatory. In rats, valdecoxib potently inhibited carrageenan footpad edema and adjuvant-induced arthritis.
Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in animal models. It is a potent and selective inhibitor of prostaglandin synthesis primarily through inhibition of COX-2. Valdecoxib is used to relieve some symptoms caused by arthritis (rheumatism), such as inflammation, swelling, stiffness, and joint pain.
Safety
| Symbol(GHS) |   GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H361d-H373-H410 |
| Precautionary statements | P201-P202-P260-P273-P280-P308+P313 |
| Hazard Codes | Xn,N |
| Risk Statements | 63-48/22-51/53 |
| Safety Statements | 36/37-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 1 Repr. 2 STOT RE 2 |
| Hazardous Substances Data | 181695-72-7(Hazardous Substances Data) |
