Vatalanib (PTK787) 2HCl , ≥99% , 212141-51-0

Synonym(s):
1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride;N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

CAS NO.：212141-51-0

Empirical Formula: C20H17Cl3N4

Molecular Weight: 419.74

MDL number: MFCD08458964

PRODUCT Properties

• Melting point: 268-2700C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
• form: solid
• color: White or off-white
• Water Solubility: H2O: 2mg/mL, clear
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 212141-51-0

Description and Uses

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC₅₀ values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P271-P280
• Risk Statements: 36/37/38
• Safety Statements: 24/25
• HS Code: 29333990