Wortmannin , 98% , 19545-26-7

Synonym(s):
Antibiotic SL-2052;KY 12420;KY 12420, MLCK Inhibitor II;Wortmannin - CAS 19545-26-7 - Calbiochem

CAS NO.：19545-26-7

Empirical Formula: C23H24O8

Molecular Weight: 428.43

MDL number: MFCD00133927

EINECS: 606-337-5

PRODUCT Properties

• Melting point: 234-240 °C
• alpha: +80.0～+105.0゜(20℃/D)(c=0.1,C2H5OH)
• Boiling point: 463.31°C (rough estimate)
• Density: 1.2454 (rough estimate)
• refractive index: 1.4480 (estimate)
• Flash point: 2℃
• storage temp.: -20°C
• solubility: DMSO: soluble
• form: powder
• color: off-white
• biological source: Penicillium funiculosum
• Sensitive: Light Sensitive
• λmax: 296nm(lit.)
• Merck: 14,10053
• BRN: 67676
• Stability: Stable for 1 year from date of purchase as supplied. Dried aliquots evaporated from ethanol may be stored at -20° for several months. Solutions however are not stable and must be used within one working day. Note

Description and Uses

Wortmannin (19545-26-7) is a potent and selective inhibitor of PI3-kinase which acts via covalent modification of Lys-802.2?Inhibits autophagy in rat hepatocytes.3?Inhibits adipocyte differentiation of 3T3-L1 cells.4?Wortmannin is useful tool for probing PI3-K-mediated cellular events.5

Wortmannin, Ready Made Solution has been used:

• as a phosphoinositide 3-kinase (PI3K) pathway inhibitor
• as an endoderm-inducing agent in stem cell selection and differentiation
• as a autophagy inhibitor

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300+H310+H330
• Precautionary statements: P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310
• Hazard Codes: T+,T,Xi,Xn,F
• Risk Statements: 26/27/28-36/37/38-36-20/21/22-11
• Safety Statements: 28-36/37-45-37/39-26-16
• RIDADR: UN 3462 6.1/PG 1
• WGK Germany: 3
• RTECS: CB9641000
• F: 3-8-10
• HazardClass: 6.1
• PackingGroup: I
• HS Code: 29322090