Metoclopramide hydrochloride , ≧95% , 7232-21-5

CAS NO.：7232-21-5

Empirical Formula: C14H23Cl2N3O2

Molecular Weight: 336.26

MDL number: MFCD00058011

EINECS: 206-662-9

PRODUCT Properties

• Melting point: 171-173°C
• storage temp.: 2-8°C
• solubility: H₂O: soluble
• form: solid
• color: white
• Water Solubility: H2O: soluble

Description and Uses

Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT₃ antagonist with K_i and IC₅₀ values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D₂ receptor antagonist (IC₅₀ = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED₅₀ values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (K_is = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.

A D2DR inhibitor and an HTR3E inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: BZ3325000
• HS Code: 29242990