tert-Butyl1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate , 95% , 850090-09-4

CAS NO.：850090-09-4

Empirical Formula: C17H34O8

Molecular Weight: 366.45

MDL number: MFCD27977509

PRODUCT Properties

• Boiling point: 445.4±40.0 °C(Predicted)
• Density: 1.071
• refractive index: n/D 1.448
• storage temp.: -20°C
• form: liquid
• pka: 14.36±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P305+P351+P338
• HS Code: 2918999090