BD0343032
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine , 97% , 314771-88-5
CAS NO.：314771-88-5
Empirical Formula: C18H14ClFN4O4
Molecular Weight: 404.78
MDL number: MFCD18642924
EINECS: 925-395-5
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB24.00 | In Stock |
|
| 250mg | RMB28.80 | In Stock |
|
| 1g | RMB59.20 | In Stock |
|
| 5g | RMB183.20 | In Stock |
|
| 25g | RMB624.00 | In Stock |
|
| 100g | RMB2057.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 585.0±50.0 °C(Predicted) |
| Density | 1.534±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 5.07±0.70(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C18H14ClFN4O4/c19-13-5-10(1-2-14(13)20)23-18-12-6-16(24(25)26)17(7-15(12)21-9-22-18)28-11-3-4-27-8-11/h1-2,5-7,9,11H,3-4,8H2,(H,21,22,23)/t11-/m0/s1 |
| InChIKey | UXAZURVGMXJLSO-NSHDSACASA-N |
| SMILES | N1=C2C(C=C([N+]([O-])=O)C(O[C@H]3CCOC3)=C2)=C(NC2=CC=C(F)C(Cl)=C2)N=C1 |
Description and Uses
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
