Tasquinimod , 98% , 254964-60-8

CAS NO.：254964-60-8

Empirical Formula: C20H17F3N2O4

Molecular Weight: 406.36

MDL number: MFCD18251454

PRODUCT Properties

• Boiling point: 501.5±50.0 °C(Predicted)
• Density: 1.427±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
• form: solid
• pka: 4.50±1.00(Predicted)
• color: White to light yellow
• InChI: 1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
• InChIKey: ONDYALNGTUAJDX-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1ccc(cc1)N(C)C(=O)c2[c]([n](c3c(c2O)c(ccc3)OC)C)=O

Description and Uses

Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.

Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids