1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride , 97% , 1628047-87-9

CAS NO.：1628047-87-9

Empirical Formula: C19H29Cl3N2

Molecular Weight: 391.806

MDL number: MFCD28334264

PRODUCT Properties

• storage temp.: Inert atmosphere,Room Temperature
• Appearance: White to off-white Solid
• InChI: InChI=1S/C19H27ClN2.ClH/c1-19(2)8-7-16(14-22-11-9-21-10-12-22)18(13-19)15-3-5-17(20)6-4-15;/h3-6,21H,7-14H2,1-2H3;1H
• InChIKey: NRMARNSPIXWGDD-UHFFFAOYSA-N
• SMILES: C(N1CCNCC1)C1CCC(C)(C)CC=1C1C=CC(Cl)=CC=1.Cl
• CAS DataBase Reference: 1628047-87-9

Description and Uses

1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine Dihydrochloride is an intermediate used in the preparation of Venetoclax (A112430), which is a potent and selective BCL-2 inhibitor with potent antitumour activity while sparing platelets. Venetoclax is used to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H335-H319-H315
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362