Methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoate , 98+% , 1235865-75-4

CAS NO.：1235865-75-4

Empirical Formula: C15H11FN2O3

Molecular Weight: 286.26

MDL number:

PRODUCT Properties

• Density: 1.377±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,Room Temperature
• pka: 13.21±0.40(Predicted)
• Appearance: Light yellow to yellow Solid
• InChI: InChI=1S/C15H11FN2O3/c1-20-15(19)12-3-2-10(16)7-13(12)21-11-6-9-4-5-17-14(9)18-8-11/h2-8H,1H3,(H,17,18)
• InChIKey: WOXIJNIAUMZYEL-UHFFFAOYSA-N
• SMILES: C(OC)(=O)C1=CC=C(F)C=C1OC1=CN=C2NC=CC2=C1
• CAS DataBase Reference: 1235865-75-4

Description and Uses

Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate is a pharmaceutical intermediate compound that can be used in the preparation of a bcl-2 inhibitor intermediate, methyl 4-fluoro-2-((3-fluoro-lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)benzoate. It can be used in the treatment of some cancers.

Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate is the intermediate for ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumor activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.

Safety

• Symbol(GHS): GHS07,GHS05
• Signal word: Danger
• Hazard statements: H335-H302-H318-H315
• Precautionary statements: P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362