N4-(4-Phenoxyphenethyl)quinazoline-4,6-diamine , 98% , 545380-34-5
Synonym(s):
4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine;6-Amino-4-(4-phenoxyphenylethylamino)quinazoline;N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine;NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem;QNZ
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB255.20 | In Stock |
|
| 5mg | RMB493.60 | In Stock |
|
| 10mg | RMB881.60 | In Stock |
|
| 50mg | RMB2975.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 169-175°C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChI | 1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26) |
| InChIKey | IBAKVEUZKHOWNG-UHFFFAOYSA-N |
| SMILES | NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1 |
Description and Uses
QNZ (545380-34-5) was originally described as a potent inhibitor of NF-κB activation (IC50= 11 nM) and TNF-αproduction (IC50= 7 nM).1,2It indirectly inhibits the NF-κB pathway via inhibition of store-operated calcium entry (SOC) and displayed neuroprotective effects in transgenic fly and mouse models of Huntington’s disease.3,4Its target has been postulated to be heteromeric calcium channels containing TRPC1 as one of the subunits.4QNZ reduced synaptic neuronal SOC and rescued dendritic spine loss in YAC128 striatal medium spiny neurons.5QNZ has also been identified as a potent (IC50= 25 nM complex 1 fromY.lipolytica; IC50= 14 nM complex 1 fromBos Taurusheart mitochondria) and selective inhibitor of mitochondrial complex I.6QNZdecreased PSEN1ΔE9-mediated nSOCE upregulation and rescued mushroom spines in PSEN1ΔE9-expressing neurons, which are linked to familial Alzheimer’s disease.7
QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-a production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1m
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
