1-(9,10-Dihydro-6H-6,10-methanoazepino[4,5-g]quinoxalin-8(7H)-yl)-2,2,2-trifluoroethanone , 98+% , 230615-70-0

CAS NO.：230615-70-0

Empirical Formula: C15H12F3N3O

Molecular Weight: 307.27

MDL number: MFCD23701601

PRODUCT Properties

• Melting point: 164-166 ºC
• Boiling point: 491.9±45.0 °C(Predicted)
• Density: 1.449
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: 1.50±0.20(Predicted)
• form: Solid
• color: White to Off-White
• InChI: InChI=1S/C15H12F3N3O/c16-15(17,18)14(22)21-6-8-3-9(7-21)11-5-13-12(4-10(8)11)19-1-2-20-13/h1-2,4-5,8-9H,3,6-7H2
• InChIKey: XDLHBWIAJAKYKF-UHFFFAOYSA-N
• SMILES: C(=O)(N1CC2CC(C3=CC4=NC=CN=C4C=C32)C1)C(F)(F)F

Description and Uses

7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (N-(trifluoroacetyl)varenicline) is an important pharmaceutical intermediate compound which is used in the preparation of varenicline. Varenicline is an oral smoking cessation aid drug. It works by blocking the pleasant effects of nicotine (from smoking) on the brain.

7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is used to prepare varenicline, which is a smoking cessation. It is a Varenicline protected impurity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338