Varenicline-d4 , 98% , 2183239-01-0

CAS NO.：2183239-01-0

Empirical Formula: C13H13N3

Molecular Weight: 211.27

MDL number:

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: Water: 0.0877 mg/mL
• form: A solid
• Water Solubility: Water: 0.0877 mg/mL

Description and Uses

Varenicline-d₄ is intended for use as an internal standard for the quantification of varenicline by GC- or LC-MS. Varenicline is a full agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs; EC₅₀ = 18 μM) and a partial agonist of α4β2 subunit-containing nAChRs (EC₅₀ = 2.3 μM). Formulations containing varenicline have been used as aids in smoking cessation.

Varenicline-d4 is deuterium labeled Varenicline. Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively[1]. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment[2].