![(S)-3-Chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile](https://img.chemicalbook.com/CAS/20200611/GIF/2227425-05-8.gif)
BD2733545
(S)-3-Chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile , 98+% , 2227425-05-8
CAS NO.：2227425-05-8
Empirical Formula: C15H14ClF3N4O2
Molecular Weight: 374.75
MDL number:
EINECS: 604-604-1
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB728.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 599.2±50.0 °C(Predicted) |
| Density | 1.57±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 1 mg/mL; DMSO: 1mg/mL; Ethanol: 10mg/mL; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL |
| form | A crystalline solid |
| pka | 11.78±0.40(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1 |
| InChIKey | ATFQBBCQZKVZJN-QMMMGPOBSA-N |
| SMILES | C12C(Cl)=C(C)NC1=C(N1CCO[C@H](CO)C1)C(C#N)=C(C(F)(F)F)N=2 |
Description and Uses
PF-06869206 is an orally bioavailable inhibitor of sodium-phosphate cotransporter 2a (NaPi2a; IC50 = 380 nM). It is selective for NaPi2a over NaPi2b, NaPi2c, PiT-1, and PiT-2 (IC50s = >25 μM).
PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM[1].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
