(S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoicacidhydrochloride , 97% , 67953-08-6

Synonym(s):
L-γ-Glutamyl-p-nitroanilide

CAS NO.：67953-08-6

Empirical Formula: C11H14ClN3O5

Molecular Weight: 303.7

MDL number: MFCD00039054

EINECS: 267-944-5

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: Soluble in Water (up to 5 mg/ml).
• form: solid
• color: Off-white
• Water Solubility: water: 5mg/mL, clear, yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
• InChI: 1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H
• InChIKey: OJEVFSFTVARWQX-UHFFFAOYSA-N
• SMILES: Cl.NC(CCC(=O)Nc1ccc(cc1)N(=O)=O)C(O)=O
• EPA Substance Registry System: L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6)

Description and Uses

L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3

L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• PPE: Eyeshields, Gloves, type N95 (US)
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: TSCA listed
• Storage Class: 11 - Combustible Solids