ProchlorperazineDimaleate , 95% , 84-02-6

Synonym(s):
Prochlorperazine dimaleate salt

CAS NO.：84-02-6

Empirical Formula: C28H32ClN3O8S

Molecular Weight: 606.09

MDL number: MFCD00069330

EINECS: 201-511-3

PRODUCT Properties

• Melting point: 1750C
• storage temp.: 2-8°C
• solubility: Very slightly soluble in water and in ethanol (96 per cent).
• pka: pKa 8.1(H2O,t =24±1) (Uncertain)
• form: solid
• color: White
• Water Solubility: H2O: slightly soluble 0.3mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3mg/mL; methanol: soluble
• λmax: 313nm(MeOH)(lit.)
• Merck: 14,7761
• Stability: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Description and Uses

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Antiemetic;Dopamine antagonist

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H336-H361d-H362
• Precautionary statements: P202-P260-P263-P264-P301+P312-P308+P313
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: SO3150000
• HS Code: 2934302300
• Toxicity: LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier)