(E)-6-Iodo-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole , 98% , 886230-77-9

CAS NO.：886230-77-9

Empirical Formula: C19H18IN3O

Molecular Weight: 431.27

MDL number:

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 156-159°C
• Boiling point: 561.2±50.0 °C(Predicted)
• Density: 1.60
• storage temp.: 2-8°C(protect from light)
• solubility: Chloroform, DMSO, Methanol
• form: Solid
• pka: 4.25±0.10(Predicted)
• color: Light Yellow
• Stability: Hygroscopic, Light Sensitive
• InChI: InChI=1S/C19H18IN3O/c20-14-7-9-16-17(10-8-15-5-1-3-11-21-15)22-23(18(16)13-14)19-6-2-4-12-24-19/h1,3,5,7-11,13,19H,2,4,6,12H2/b10-8+
• InChIKey: QXJFRDDGGSSQDX-CSKARUKUSA-N
• SMILES: N1(C2OCCCC2)C2=C(C=CC(I)=C2)C(/C=C/C2=NC=CC=C2)=N1

Description and Uses

(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole is an intermediate used to prepare Axitinib (A794650) . Axitinib is used in cancer therapy. Axitinib (AG-013736) is a selective small molecule inhibitor of VEGF receptor tyrosine kinases 1, 2 and 3 and the platelet-derived growth factor (PDGF) receptor that targets the catalytic domain of the tyrosine kinase and induces ATP-competitive inhibition with limited activity against other protein kinases . It is an indazole derivative, its molecular formula is C22H18N4OS and its molecular weight is 386.5 Da^[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P305+P351+P338