tert-Butyl1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate , 95% , 778596-26-2

CAS NO.：778596-26-2

Empirical Formula: C27H54O13

Molecular Weight: 586.71

MDL number: MFCD28385467

PRODUCT Properties

• storage temp.: Storage temp. 2-8°C
• solubility: Soluble in Water, DMSO, DMF, DCM
• form: Liquid
• color: Colorless to light yellow
• InChI: InChI=1S/C27H54O13/c1-27(2,3)40-26(29)4-6-30-8-10-32-12-14-34-16-18-36-20-22-38-24-25-39-23-21-37-19-17-35-15-13-33-11-9-31-7-5-28/h28H,4-25H2,1-3H3
• InChIKey: AEEGJXDZOJNBIY-UHFFFAOYSA-N
• SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

Description and Uses

Hydroxy-PEG10-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338