Ramiprilate , 95% , 87269-97-4

CAS NO.：87269-97-4

Empirical Formula: C21H28N2O5

Molecular Weight: 388.46

MDL number: MFCD00865787

EINECS: 258-696-9

PRODUCT Properties

• Melting point: 139-141°C
• Boiling point: 632.2±55.0 °C(Predicted)
• Density: 1.273±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 2.20±0.10(Predicted)
• color: White to Pale Yellow
• Stability: Hygroscopic
• InChIKey: KEDYTOTWMPBSLG-HILJTLORSA-N
• SMILES: N1(C(=O)[C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)[C@H](C(O)=O)C[C@]2([H])CCC[C@]12[H]

Description and Uses

Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pK_i = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B₂ kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.

A metabolite of Ramipril (R111000).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/38
• Safety Statements: 26-37/39