5,7-Dichloropyrazolo[1,5-a]pyrimidine , 97% , 57489-77-7

CAS NO.：57489-77-7

Empirical Formula: C6H3Cl2N3

Molecular Weight: 188.01

MDL number: MFCD08273918

PRODUCT Properties

• Melting point: 68-71 °C(Solv: ethanol (64-17-5))
• Density: 1.69±0.1 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• pka: -1.68±0.30(Predicted)
• form: Solid
• color: Off-white to yellow
• InChI: InChI=1S/C6H3Cl2N3/c7-4-3-5(8)11-6(10-4)1-2-9-11/h1-3H
• InChIKey: JMTFWCYVZOFHLR-UHFFFAOYSA-N
• SMILES: C12=CC=NN1C(Cl)=CC(Cl)=N2

Description and Uses

5,7-Dichloropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate compound that can be used in a palladium-catalysed pharmaceutical synthesis cross-coupling reaction. 2,4-Dichloroquinoline reacts with benzylzinc and phenylzinc reagents in the presence of catalytic quantities of palladium complexes to yield only α-substituted products.2,4-Dichloroquinolines have been found to react with benzylzinc and phenylzinc reagents in catalytic amounts of palladium compounds to produce only α-substituted products. LiCl was found to be an effective additive for γ-selective coupling reactions. These α- or γ-selective coupling conditions are applicable to the reaction of 5,7-Dichloropyrazolo[1,5-a]pyrimidine and biphenylmethyl zinc reagents in the synthesis of angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other α,γ-dichloropyrazine systems^[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H332-H335
• Precautionary statements: P261-P280-P305+P351+P338
• HS Code: 2933599590