Roscovitine , 98% , 186692-46-6
Synonym(s):
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol;2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I;6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine;Roscovitine - CAS 186692-46-6 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB316.80 | In Stock |
|
| 10mg | RMB540.00 | In Stock |
|
| 50mg | RMB1401.60 | In Stock |
|
| 100mg | RMB2157.60 | In Stock |
|
| 250mg | RMB3645.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 106～107℃ |
| Boiling point: | 577.5±60.0 °C(Predicted) |
| Density | 1.3 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml). |
| form | White to off-white solid |
| pka | 14.56±0.10(Predicted) |
| color | White |
| biological source | synthetic (organic) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 |
| InChIKey | BTIHMVBBUGXLCJ-OAHLLOKOSA-N |
| SMILES | C(O)[C@H](NC1=NC(NCC2=CC=CC=C2)=C2C(=N1)N(C(C)C)C=N2)CC |
| CAS DataBase Reference | 186692-46-6(CAS DataBase Reference) |
Description and Uses
Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. ?p34 cdc2 IC50 = 0.2 μM.? Also inhibits p33cdk2 and p33cdk5.1? Anti-angiogenic.2 Prevents PPARg S273 phosphorylation, promoting browning of white adipose tissue.3 Enhances peripheral nerve regrowth.4
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung cancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29335990 |
