Deferoxaminemesylate , 98% , 138-14-7

Synonym(s):
Deferoxamine mesylate salt;DFOM;Deferoxamine methanesulfonate salt;Desferrioxamine mesylate salt;Desferrioxamine Mesylate, DFOM, Iron Chelator II

CAS NO.：138-14-7

Empirical Formula: C26H52N6O11S

Molecular Weight: 656.79

MDL number: MFCD00058605

EINECS: 205-314-3

PRODUCT Properties

• Melting point: 148-149°
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL
• form: powder
• color: white to off-white
• Water Solubility: Soluble to 100 mM in water
• InChIKey: IDDIJAWJANBQLJ-UHFFFAOYSA-N
• SMILES: C(=O)(N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN)CCC(=O)NCCCCCN(O)C(=O)C.S(=O)(=O)(O)C

Description and Uses

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC₅₀ = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

chelating agent (Fe & Al)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: UG5310000
• HS Code: 29280000
• Toxicity: man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.