6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole , 95% , 1231930-33-8

CAS NO.：1231930-33-8

Empirical Formula: C11H12BrFN2

Molecular Weight: 271.13

MDL number: MFCD16660227

PRODUCT Properties

• Boiling point: 353.4±22.0 °C(Predicted)
• Density: 1.49
• storage temp.: Sealed in dry,Room Temperature
• pka: 3.48±0.10(Predicted)
• Appearance: Off-white to yellow Solid
• InChI: InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3
• InChIKey: SJQZRZLUEGCXFN-UHFFFAOYSA-N
• SMILES: C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1

Description and Uses

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
• HS Code: 2933998090