A7134512
Rucaparib (AG-014699,PF-01367338) , ≥99% , 459868-92-9
CAS NO.：459868-92-9
Empirical Formula: C19H21FN3O5P
Molecular Weight: 421.37
MDL number: MFCD17010269
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB364.00 | In Stock |
|
| 10MG | RMB951.20 | In Stock |
|
| 50MG | RMB2603.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >173°C (dec.) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Yellow solid. |
| color | Yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Description and Uses
Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1?Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2?Demonstrates antiproliferative effects in 26 out of 39 ovarian cancer cell lines.3?Synergizes with other anticancer agents such as topotecan, carboplatin, doxorubicin, paclitaxel,3 and temozolomide.4?Ameliorates the cardiotoxicity of doxorubicin.5?Recently approved for human use by the FDA.
PARP inhibitor oncolytic
Safety
| Symbol(GHS) |   GHS07,GHS02 |
| Signal word | Warning |
| Hazard statements | H315-H319-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
