4-Amino-1,8-naphthalimide , 95% , 1742-95-6

CAS NO.：1742-95-6

Empirical Formula: C12H8N2O2

Molecular Weight: 212.2

MDL number: MFCD00006921

EINECS: 217-110-1

PRODUCT Properties

• Melting point: 360 °C
• Boiling point: 352.04°C (rough estimate)
• Density: 1.105 g/mL at 25 °C(lit.)
• vapor pressure: 0Pa at 25℃
• refractive index: 1.6000 (estimate)
• storage temp.: -20°C
• solubility: Soluble in DMSO
• form: Orange solid.
• pka: 9.53±0.20(Predicted)
• color: Yellow to brown
• Water Solubility: 354mg/L at 25℃
• Cosmetics Ingredients Functions: HAIR DYEING
• InChI: 1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
• InChIKey: SSMIFVHARFVINF-UHFFFAOYSA-N
• SMILES: Nc1ccc2C(=O)NC(=O)c3cccc1c23
• LogP: 1.08
• CAS DataBase Reference: 1742-95-6
• EPA Substance Registry System: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino- (1742-95-6)

Description and Uses

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC₅₀ = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: DE4081000
• TSCA: TSCA listed
• HS Code: 29251995
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3