(Z)-3-(Dimethylamino)propane-1,2-diyldioleate , 98% , 127512-29-2

Synonym(s):
1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

CAS NO.：127512-29-2

Empirical Formula: C41H77NO4

Molecular Weight: 648.05

MDL number: MFCD01321074

PRODUCT Properties

• Boiling point: 670.1±55.0 °C(Predicted)
• Density: 0.916±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under Inert Atmosphere
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• form: Oil
• pka: 8.02±0.28(Predicted)
• color: Colourless to Light Yellow
• Stability: Light Sensitive; Hydroscopic; Store at -15 to -25°C
• InChIKey: NYDLOCKCVISJKK-WRBBJXAJSA-N
• SMILES: C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC

Description and Uses

DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).

DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5].

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H331-H336-H351-H361d-H372
• Precautionary statements: P202-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313
• target organs: Liver,Kidney, Respiratory system
• WGK Germany: WGK 3
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3; toxic hazardous materials or hazardous materials causing chronic effects
• Hazard Classifications: Acute Tox. 3 Inhalation; Acute Tox. 4 Oral; Carc. 2; Eye Irrit. 2; Repr. 2; Skin Irrit. 2; STOT RE 1 Oral; STOT SE 3