(Z)-3-(Dimethylamino)propane-1,2-diyldioleate , 98% , 127512-29-2

Synonym(s):
1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

CAS NO.：127512-29-2

Empirical Formula: C41H77NO4

Molecular Weight: 648.05

MDL number: MFCD01321074

Pack Size	Price	Stock	Quantity
100mg	RMB714.40	In Stock
250mg	RMB1142.40	In Stock
1g	RMB2968.80	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Boiling point:	670.1±55.0 °C(Predicted)
Density	0.916±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Oil
pka	8.02±0.28(Predicted)
color	Colourless to Light Yellow
Stability:	Light Sensitive; Hydroscopic; Store at -15 to -25°C
InChIKey	NYDLOCKCVISJKK-WRBBJXAJSA-N
SMILES	C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC

Description and Uses

DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).

DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation[1][2][3][4][5].

Safety

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary statements	P202-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313