O-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)hydroxylamine , 95% , 1835759-78-8

CAS NO.：1835759-78-8

Empirical Formula: C11H21NO5

Molecular Weight: 247.29

MDL number: MFCD29052160

PRODUCT Properties

• Boiling point: 353.6±37.0 °C(Predicted)
• Density: 1.078±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C, sealed storage, away from moisture and light
• form: Liquid
• pka: 4.21±0.70(Predicted)
• color: Colorless to light yellow

Description and Uses

Aminooxy-PEG4-propargyl is a aldehyde reactive crosslinker. The aminooxy group reacts with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H315-H319-H228
• Precautionary statements: P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313