Propargyl-PEG2-methylamine , 1835759-76-6

CAS NO.：1835759-76-6

Empirical Formula: C8H15NO2

Molecular Weight: 157.21

MDL number:

PRODUCT Properties

• Boiling point: 214.6±20.0 °C(Predicted)
• Density: 0.947±0.06 g/cm3(Predicted)
• solubility: Soluble in Water, DMSO, DCM, DMF
• pka: 9.50±0.10(Predicted)

Description and Uses

Propargyl-PEG2-methylamine is a crosslinker with a propargyl group and methylamine group. The propargyl group forms triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1].