tert-Butyl1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate , 98% , 361189-64-2

Synonym(s):
tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate;HO-PEG6-CO-OtBu

CAS NO.：361189-64-2

Empirical Formula: C19H38O9

Molecular Weight: 410.5

MDL number: MFCD13185017

PRODUCT Properties

• Boiling point: 481.8±40.0 °C(Predicted)
• Density: 1.076±0.06 g/cm3(Predicted)
• refractive index: n/D 1.454
• storage temp.: -20°C
• pka: 14.36±0.10(Predicted)
• form: viscous liquid
• color: Colourless
• InChI: InChI=1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• InChIKey: VGGDPFAYSOSIOK-UHFFFAOYSA-N
• SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCO

Description and Uses

Hydroxy-PEG6-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
• WGK Germany: WGK 3
• HS Code: 2942000090
• Storage Class: 10 - Combustible liquids