(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione , 99.9% , 2873-36-1

CAS NO.：2873-36-1

Empirical Formula: C11H18N2O2

Molecular Weight: 210.27

MDL number: MFCD00237617

EINECS: 220-710-6

PRODUCT Properties

• Melting point: 163-165℃
• Boiling point: 427.6±34.0 °C(Predicted)
• Density: 1.14
• storage temp.: Inert atmosphere,2-8°C
• solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
• form: Solid
• pka: 13.27±0.40(Predicted)
• color: White to Off-White

Description and Uses

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC₅₀ value of 0.15 mM.

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H317
• Precautionary statements: P280
• Toxicity: mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.