3-Methyl-1H-indazole , 98% , 3176-62-3

CAS NO.：3176-62-3

Empirical Formula: C8H8N2

Molecular Weight: 132.16

MDL number: MFCD00601361

EINECS: 1533716-785-6

PRODUCT Properties

• Melting point: 113°C
• Boiling point: 234.08°C (rough estimate)
• Density: 1.1083 (rough estimate)
• refractive index: 1.6013 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• form: solid
• pka: 14.39±0.40(Predicted)
• Appearance: Off-white to light brown Solid
• InChI: InChI=1S/C8H8N2/c1-6-7-4-2-3-5-8(7)10-9-6/h2-5H,1H3,(H,9,10)
• InChIKey: FWOPJXVQGMZKEP-UHFFFAOYSA-N
• SMILES: N1C2=C(C=CC=C2)C(C)=N1

Description and Uses

3-Methyl-1H-indazole is a heterocyclic alkyl compound containing nitrogen and three methyl groups. It is used as an intermediate in the synthesis of other compounds. It has been shown to have anti-inflammatory properties in vitro. It also inhibits neutrophil chemotaxis and may be used to treat inflammatory diseases such as trigeminal neuralgia or heart disease. 3-Methyl-1H-indazole has also been shown to inhibit histamine H3 receptor activity, which may account for its effects on eye diseases and bladder cancer.

3-Methyl-1H-indazole is an intermediate compound. It can be used as an organic synthesis reagent for the preparation of 3-methyl-1H-indazol-5-amine and 3-methyl-5-nitro-1H-indazole compounds. In addition, the 3-Methyl-1H-indazole derivatives (1a-1d and 2a-2d) have antimicrobial effects, both having antibacterial activity against Bacillus subtilis and Escherichia coli^[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H317-H319-H335
• Precautionary statements: P261-P280-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22
• HS Code: 2933998090