![S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA](https://img.chemicalbook.com/CAS/GIF/37686-84-3.gif)
LN-018232
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA , NLT 98% , 37686-84-3
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 203-204° (dec); mp 205-207° (dec) (Cerny) |
| alpha | D20 +30° (c = 1 in pyridine); D20 +29.0° (c = 0.2 in pyridine) |
| Boiling point: | 476.25°C (rough estimate) |
| Density | 1.1056 (rough estimate) |
| refractive index | 1.6620 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 13.60±0.20(Predicted) |
| color | white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
Description and Uses
Terguride (37686-84-3) is a semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys.1?Partial agonist at recruitment of β-arrestin2 to the D2 receptor.2 Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.3
An ergot alkaloid derivative that acts as a partial dopamine D2-receptor agonist. An anti-hyperprolactinemia agent.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H331-H311 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | YS9378700 |
| Toxicity | LD50 oral in rat: 100mg/kg |
