Dolutegravir 2-Desfluoro Impurity , 0.95 , 1863916-88-4

CAS NO.：1863916-88-4

Empirical Formula: C20H20FN3O5

Molecular Weight: 401.39

MDL number:

Update time: 2023-04-23

PRODUCT Properties

Boiling point:	675.7±55.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	4.50±1.00(Predicted)
color	Off-White to Light Brown

Description and Uses

Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Safety

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338

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