LN-918027
DEOXYGALACTONOJIRIMYCIN, HYDROCHLORIDE , 98%+ , 108147-54-2
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 243-245 °C |
| Boiling point: | 361.1±42.0 °C(Predicted) |
| Density | 1.456±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 13.77±0.70(Predicted) |
Description and Uses
Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity[1].
