N-(4-Acetamidophenyl)indomethacin amide , ≥95% , 261766-23-8

CAS NO.：261766-23-8

Empirical Formula: C27H24ClN3O4

Molecular Weight: 489.95

MDL number: MFCD02683236

PRODUCT Properties

• Melting point: 256-257°C
• storage temp.: −20°C
• solubility: DMSO: ≥15 mg/mL
• form: crystalline
• color: Pale Yellow

Description and Uses

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Safety

• WGK Germany: 3