PRODUCT Properties
| Melting point: | 52-53° |
| Boiling point: | bp0.1 121-122° |
| Density | 1.1255 (rough estimate) |
| refractive index | 1.5440 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 2.8g/L(25 ºC) |
Description and Uses
Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents. Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides. Methsuximide has been shown to have anticonvulsant properties in clinical trials.
A calcium channel succinimide antiepileptic drug. Anticonvulsant.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H412 |
| Precautionary statements | P264-P270-P273-P301+P312-P501 |
| HS Code | 2925190100 |
| Hazardous Substances Data | 77-41-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in mice: 0.9 g/kg (Marshall, Vallance) |
