Brinzolamide-d5 , ≥99% , 1217651-02-9

CAS NO.：1217651-02-9

Empirical Formula: C12H21N3O5S3

Molecular Weight: 383.5

MDL number:

PRODUCT Properties

• storage temp.: Refrigerator
• solubility: Ethanol
• form: Solid
• color: Crystalline

Description and Uses

Brinzolamide-d₅ is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC₅₀s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC₅₀ = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.

Carbonic anhydrase inhibitor. Antiglaucoma agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning