AG-370 , ≥98% , 134036-53-6

CAS NO.：134036-53-6

Empirical Formula: C15H9N5

Molecular Weight: 259.27

MDL number: MFCD00236449

PRODUCT Properties

• Boiling point: 714.1±60.0 °C(Predicted)
• Density: 1.396±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: DMSO: soluble
• pka: 15.95±0.30(Predicted)
• form: Yellow solid.
• color: White to yellow

Description and Uses

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC₅₀ value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC₅₀ = 820 μM).

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

Safety

• Safety Statements: 22-24/25
• WGK Germany: 3