L-trans-2,4-PDC , ≥98% , 64769-66-0
Synonym(s):
(2S,4R)-Pyrrolidine-2,4-Dicarboxylic Acid;trans-4-Carboxy-L -proline;L -trans-2,4-PDC
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB2996.00 | In Stock |
|
| 50mg | RMB12612.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 214-217oC |
| storage temp. | Store at RT |
| solubility | PBS (pH 7.2): 2 mg/ml |
| form | White solid. |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| InChI | InChI=1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1 |
| InChIKey | NRSBQSJHFYZIPH-DMTCNVIQSA-N |
| SMILES | N1C[C@H](C(O)=O)C[C@H]1C(O)=O |
Description and Uses
L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes). It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX. It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens. It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats.
L-trans-Pyrrolidine-2,4-dicarboxylic Acid is an inhibitor of the glutamate transporter EAAT.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
