ProstaglandinE2EthanolamideMaxSpec?Standard , ≥98% , 194935-38-1

CAS NO.：194935-38-1

Empirical Formula: C22H37NO5

Molecular Weight: 395.53

MDL number: MFCD00797645

PRODUCT Properties

• Boiling point: 611.5±55.0 °C(Predicted)
• Density: 1.134±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/mlPBS (pH 7.2): 12 mg/ml
• pka: 13.79±0.60(Predicted)
• form: powder
• InChIKey: GKKWUSPPIQURFM-IGDGGSTLSA-N
• SMILES: O[C@@H]1CC([C@H](C/C=C\CCCC(NCCO)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O

Description and Uses

Prostaglandin E₂ ethanolamide (PGE₂-EA) is an analog of PGE₂ with improved water solubility and stability. PGE₂-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; ) and acts as an agonist at E prostanoid (EP) receptors 1-4 (K_is = 2.45, 0.46, 0.2, and 0.51 μM, respectively). It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC₅₀s = 5.7 and 4.7 μM, respectively). PGE₂-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes. Ex vivo, PGE₂-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.

Prostaglandin E2 Ethanolamide-d4 is the isotope labelled analogue of Prostaglandin E2 Ethanolamide, an analogue of Prostaglandin E2 (P838610). Prostaglandin E2 is most common and most biologically potent of mammalian prostaglandins.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
• WGK Germany: WGK 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 4 Oral; Repr. 1B