PDDHV , ≥98% , 179469-40-0
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB516.00 | In Stock |
|
| 5mg | RMB2224.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | −20°C |
| solubility | Methanol: soluble |
| form | A solid |
Description and Uses
PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It induces Ca2+-uptake by rat dorsal root ganglion neurons with an EC50 value of 70 nM.
PDDHV is a calcium absorption inducer and may achieve 45Ca2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats[1].
Safety
| Symbol(GHS) |   GHS06,GHS07 |
| Signal word | Danger |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28-36/37/38 |
| Safety Statements | 26-27-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
