LE300 , ≥98% , 274694-98-3
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB3928.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >91°C (dec.) |
| Boiling point: | 463.969±40.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.115±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: 26 mg/mL |
| pka | 17.499±0.20(predicted) |
| form | solid |
| color | Off-White to Pale Beige |
| Stability: | Hygroscopic |
Description and Uses
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
LE 300 is a potent and selective dopamine receptor antagonist.
Safety
| WGK Germany | 3 |
