FR122047hydrochloride , ≥98% , 130717-51-0

Synonym(s):
1-[(4,5-Bis(4-methoxyphenyl)-2-thiazoyl)carbonyl]-4-methylpiperazine hydrochloride;COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem;FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

CAS NO.：130717-51-0

Empirical Formula: C23H26ClN3O3S

Molecular Weight: 459.99

MDL number: MFCD00925604

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: methylene chloride: 50 mg/mL, slightly hazy, yellow
• form: powder
• color: faint yellow
• biological source: synthetic (organic)
• Water Solubility: Soluble to 10 mM in water
• InChI: 1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H
• InChIKey: YWMAVHIKOAOSFM-UHFFFAOYSA-N
• SMILES: Cl[H].COc1ccc(cc1)-c2nc(sc2-c3ccc(OC)cc3)C(=O)N4CCN(C)CC4

Description and Uses

FR122047 is a selective inhibitor of COX-1. The IC₅₀ values for inhibition of human COX-1 and COX-2 are 0.028 and 65 μM, respectively. In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC₅₀ of 180-200 nM, which is nearly 100 times more potent than aspirin. Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.

FR 122047 Hydrochloride is a selective cyclooxygenase-1 (Cox-1) inhibitor.

Safety

• PPE: Eyeshields, Gloves, type N95 (US)
• Safety Statements: 22-24/25
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids