9-Amino-6-chloro-2-methoxyacridine , ≥98% , 3548-09-2

CAS NO.：3548-09-2

Empirical Formula: C14H11ClN2O

Molecular Weight: 258.7

MDL number: MFCD07374304

PRODUCT Properties

• Melting point: >250°C
• Boiling point: 475.1±35.0 °C(Predicted)
• Density: 1.367±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: Solubility Insoluble in water; soluble in N, N-dimethylformamide, dimethyl sulfoxide
• form: Solid
• pka: 8.6(at 25℃)
• color: Yellow
• PH Range: Weak blue B uorescence (7.5) to strong blue B uorescence (9.8)
• Appearance: Solid Powder
• λmax: 412nm
• Biological Applications: Antimalarial; bactericidal; detection of cancer cells,nucleic acids; treating malformed proteins causing neurodegenerative disease
• Major Application: Sensors, detection method for DNA amplification, inhibition of neurode-generative diseases, RNA hydrolysis, fluorescent probes, primers for nucleic acid sequencing, synthesis of nucleic acids, antimalerial agent

Description and Uses

9-Amino-6-chloro-2-methoxyacridine (ACMA) is a cell-permeable fluorescent probe for labeling DNA with selectivity for poly(dA-dT) sequences. ACMA fluorescence is quenched when a pH gradient is established, a property that has been utilized in animal- and plant-based studies. It also inhibits acetylcholinesterase with a Ki value of 49 nM.

9-Amino-6-chloro-2-methoxyacridine is a nucleic acid stain.

Safety

• Symbol(GHS): GHS08,GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335-H351
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501
• Hazard Codes: Xn
• Risk Statements: 36/37/38-40
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: AR7330000