ProstaglandinD2-1-glycerylester , ≥98% , 309260-52-4

CAS NO.：309260-52-4

Empirical Formula: C23H38O7

Molecular Weight: 426.54

MDL number: MFCD05863733

PRODUCT Properties

• Boiling point: 618.120±55.00 °C(Press: 760.00 Torr)(predicted)
• Density: 1.183±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): .1 mg/ml
• pka: 13.541±0.10(predicted)

Description and Uses

2-Arachidonoyl glycerol (2-AG; ) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB₁ receptor.^1,2 Incubation of 2-AG with COX-2 and specific prostaglandin H₂ (PGH₂; ) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.³ The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. In RAW 264.7 cells, PGD₂-2-glyceryl ester is the main COX metabolite.³ The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 mixture of the 1- and 2-glyceryl esters in typical aqueous media. While the stability and metabolism of these PG products have been investigated, little is known about their intrinsic biological activity.⁴

Prostaglandin D2-1-glyceryl ester (PGD2-G; PGD2 2-glyceryl ester)[1].