8-isoProstaglandinF2β , ≥98% , 177020-26-7

CAS NO.：177020-26-7

Empirical Formula: C20H34O5

Molecular Weight: 354.48

MDL number: MFCD00216066

PRODUCT Properties

• Boiling point: 531.0±50.0 °C(Predicted)
• Density: 1.153±0.06 g/cm3(Predicted)
• solubility: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)
• pka: 4.76±0.10(Predicted)

Description and Uses

8-iso Prostaglandin F_2β (8-iso PGF_2β) is an isomer of PGF_2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF_2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF_2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF_2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE₁, 8-iso PGE₂, or 8-iso PGF_2α

8-iso Prostaglandin F2β (8-iso PGF2β) is a biomarker for assessing oxidative stress, and its content in serum can indirectly reflect the level of oxidative stress[1].

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger