12(S)-HpETE(solutioninethanol) , ≥98% , 71774-10-2

CAS NO.：71774-10-2

Empirical Formula: C20H32O4

Molecular Weight: 336.47

MDL number: MFCD00063585

PRODUCT Properties

• Boiling point: 518.0±50.0 °C(Predicted)
• Density: 1.013±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
• form: Liquid.
• pka: 4.75±0.10(Predicted)

Description and Uses

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B₄ (LTB₄), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca²⁺/calmodulin-dependent protein kinase II from rat brain cortex.

12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501